Endocrine Abstracts

Objectives: 1. Discuss the criteria for clinical and research poster scientific abstracts.2. Identify resources available to facilitate development of an effective abstract and poster presentation for the novice or experienced nurse.3. List key components of a research abstract and poster and common errors to avoid.Every year at the ECE conference someone will mention that they would like to present an abstra...

Congenital adrenal hyperplasia (CAH) describes a group of autosomal recessive disorders characterized by impaired cortisol biosynthesis. The most common form of CAH is due to 21-hydroxylase deficiency and there is a wide range of phenotypes. The challenge in management of CAH in childhood is promotion of normal growth and development. The morbidities associated with currently available therapeutic regimens are related to glucocorticoid and/or androgen excess, intertwined with ...

Context: Endogenous Cushing’s syndrome (CS) may have different effects in children than what has been described in adults. Prior studies of children and adolescents with CS have identified cognitive decline despite reversal of brain atrophy after remission of CS, as well as residual impairment in quality of life measures. Although the observations of parents of children and adolescents with CS support personality changes, significant psychopathology has not been described...

Context: Prior studies of children with endogenous Cushing syndrome (CS) have identified cognitive decline despite reversal of brain atrophy after remission as well as residual impairment of quality of life measures. Although parental observations support personality changes with CS, significant psychopathology has not been described. We investigated the feasibility of using paediatric Patient-reported outcomes (PROMIS) using a computer interface to assess patient perception o...

Background: General anaesthesia and surgical intervention in humans are known to affect the function of the hypothalamic–pituitary–adrenal axis (HPA). In the literature there are conflicting reports about the effect of propofol, a commonly used intravenous anaesthetic agent, on HPA function.Case reports: We report two males (11 and 12 years) with ACTH-dependent Cushing syndrome (CS) who underwent inferior petrosal sinus sampling (IPSS) with gen...

Background: Various genetic syndromes have identified distinct and consistent behavior patterns. Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome first described by Dr Carney in 1985 as a complex of myxomas (cardiac, skin), spotty skin pigmentation, and endocrine over activity. CNC is caused by mutations of the PRKARIA gene that encodes the RIα regulatory subunit of Protein kinase A (PKA). We recently reported that a Prkar1a heterozyg...

Background and aims: Over 200 000 international adoptions by US families occurred between 1999–2010. Prior studies suggest that the effects of institutionalized care on growth and development may not be fully reversible. The exact mechanisms through which early life stress affect biobehavioral outcomes have yet to be determined, but environmental influences could regulate both biobehavoral outcomes through an effect on the hypothalamic-pituitary-adrenal (HPA) axis.<p ...